ABSTRACT
DNA intercalators such as 9-aminoacridine derivatives, have been researched for their effectiveness as cancer treatments. They inhibit the DNA topoisomerase II and induce apoptosis in the cell, however, they cannot differentiate between cancerous and noncancerous cells. O-(4-methyl)-phenyl-N-(9’-acridinyl)-hydroxylamine, a 9-aminoacridine derivative, attempting to be synthesized, is a novel anti tumor drug. This drug is designed to be less susceptible to hydrolysis, making smaller dosages more effective in eradicating cancer as well a wider therapeutic window. Once the synthesis of O-(4-methyl)-phenyl-N-(9’-acridinyl)-hydroxylamine is successful the drug will be researched further in order to determine its properties and how it binds to the DNA.
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